Donald Cram Quotes

Powerful Donald Cram for Daily Growth

About Donald Cram

Donald James Cram (December 13, 1919 – August 6, 2001) was an American organic chemist who made significant contributions to the field, earning him the Nobel Prize in Chemistry in 1986, shared with Charles J. Pedersen and Jean-Marie Lehn for their development of molecules designed to recognize and bind specific ions and molecules (receptors and molecular recognition). Born in Los Angeles, California, Cram was the son of Donald John Cram, a real estate broker, and Clara Louise Anderson. He developed an early interest in chemistry, which was fostered by his high school teacher. Cram went on to attend the University of Colorado, earning his Bachelor's degree in 1940. He then pursued a Ph.D. in organic chemistry at the California Institute of Technology (Caltech), where he worked under Linus Pauling. Cram's career was marked by numerous groundbreaking contributions. His work on the conformations of alicyclic and aliphatic compounds, published in 1952, became a cornerstone of modern organic chemistry. In the late 1960s, Cram began research on chiral molecules and their reactions, which led to the development of the "Cram's rule" for predicting stereoselectivity in organic reactions. In 1963, Cram joined Harvard University as a full professor, where he continued his influential work until his retirement in 1987. His major works include "Stereochemistry of Organic Reactions" (1955), "Molecular Recognition and the Design of Bioactive Molecules" (1988), and "The Art and Science of Organic Synthesis" (1990). Cram's work not only expanded our understanding of organic chemistry but also paved the way for advancements in medicine, materials science, and other fields. His legacy continues to inspire chemists around the world.

Interpretations of Popular Quotes

"The chemist's art is the art of synthesizing new substances with properties not found in nature."

This quote by Donald Cram emphasizes the ability of chemists to create entirely new substances, which do not naturally occur in the world. It underscores the transformative power of chemistry, as chemists design and synthesize molecules with unique properties that can revolutionize various fields, such as medicine, materials science, and technology. Essentially, this quote highlights the innovative and creative aspect of chemical research, which allows scientists to expand the boundaries of what is possible in nature.


"In science, it's often necessary to take a leap into the unknown and see if you can land on your feet."

This quote encapsulates the spirit of scientific exploration and innovation. It suggests that in the pursuit of knowledge, scientists must sometimes venture into uncharted territory (take a 'leap into the unknown'), trusting their skills and intuition to navigate the challenges they may encounter. The aim is not to blindly leap without thought, but rather to take calculated risks, knowing that success might only come after testing one's abilities ('see if you can land on your feet'). In essence, the quote illustrates the courageous and curious nature of scientific endeavor.


"The only way to learn about chemistry is by doing chemistry."

This quote by Donald Cram emphasizes the hands-on, practical aspect of learning chemistry. It suggests that theoretical knowledge, while important, is not sufficient to truly understand chemistry. Only through direct experience in conducting chemical experiments and reactions can one fully grasp the principles and complexities of the subject. In other words, the best way to learn chemistry is by actively engaging with it rather than passively receiving information about it.


"Chemistry is the study of matter, but to me it's more than that. It's the study of change."

This quote emphasizes that chemistry is not just about understanding various forms of matter (solids, liquids, gases), but also about exploring how these materials transform or undergo changes. In essence, it's a discipline focused on understanding the fundamental processes that drive the transformation of one state or substance into another, thereby highlighting the dynamic and evolving nature of matter itself.


"Science is a process, not a product. You don't get science without experimentation and observation."

This quote by Donald Cram emphasizes that science is an ongoing process rather than a static end-product. It suggests that the foundation of science lies in active engagement through experimentation and observation, which leads to discoveries, advancements, and understanding of phenomena in the natural world. The implication is that the pursuit of knowledge, particularly in the realm of scientific exploration, is not merely about reaching a final destination, but instead, it's about continually asking questions, testing hypotheses, and seeking answers based on empirical evidence gathered through observation and experimentation.


An investigator starts research in a new field with faith, a foggy idea, and a few wild experiments. Eventually the interplay of negative and positive results guides the work. By the time the research is completed, he or she knows how it should have been started and conducted.

- Donald Cram

Idea, Been, By The Time, Positive Results

By the time I entered college, I had decided not to have children, a decision that was never regretted. Accordingly, I was careful to court only girls who wanted to have professional careers.

- Donald Cram

College, By The Time, Regretted

Few scientists acquainted with the chemistry of biological systems at the molecular level can avoid being inspired.

- Donald Cram

Chemistry, Level, Scientists, Biological

This is largely the methodology I've used throughout my career - that is, starting with a question as to what might be the properties of a set of compounds that could be invented which were unusual and unpredictable. Many times I've felt a bit like Columbus setting sail.

- Donald Cram

Sail, Career, Used, Compounds

To retain my fascination with chemistry, I have had to change my research fields about every 10 years.

- Donald Cram

Change, Chemistry, Retain, Fascination

We usually don't have applications in mind. They come later.

- Donald Cram

Mind, Come, Later, Applications

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