The problem of different sensitivities of distinct protein groups to lysosomal inhibitors has remained unsolved and may have served as an important trigger in the future quest for a non-lysosomal proteolytic system that may be involved in at least certain aspects of intracellular protein degradation.
- Aaron Ciechanover
Towards the end of the military service, I had to make what I assume has been the most important decision in my career: to start a residency in clinical medicine, in surgery, which was my favorite choice, or to enroll into graduate school and start a career in scientific research. It was clear to me that I was heading for graduate school.
- Aaron Ciechanover
My father left me with his love of Jewish studies and cultural life. To this very day, along with several physicians and scientist colleagues, I take regular periodical lessons taught by a Rabbinical scholar on how the Jewish law views moral and ethical problems related to modern medicine and science.
- Aaron Ciechanover
The development of methods to monitor protein dynamics in cells together with the discovery of specific and general lysosomal inhibitors have resulted in the identification of different classes of cellular proteins, long- and short-lived, and the findings of the differential effects of the inhibitors on these groups.
- Aaron Ciechanover
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